Loading... Please wait...

Our Newsletter


Frisium (Clobazam) 10mg by Sanofi Aventis 10 x 10 Tablets / Strip

  • Image 1
Price:
¥191.51130000
Weight:
2.22 Grams
Shipping:
Calculated at checkout
Bookmark and Share


Product Description

Clobazam information from DrugsUpdate 

P - Contraindicated in pregnancy
L - Contraindicated in lactation
Clobazam, (marketed under the brand names Frisium and Urbanol), is a drug which is a benzodiazepine derivative.
Pharmacodynamics
Pharmacokinetics

Clobazam binds to one or more specific GABA receptors at several sites within the CNS including the limbic system and reticular formation. Increased permeability of neuronal membrane to chloride ions results in GABA's inhibitory effect leading to hyperpolarisation and stabilisation.


Absorption
Well absorbed from the GI tract (oral); peak plasma concentrations after 1-4 hours.

Distribution
Rapidly crosses the blood-brain barrier. Protein-binding: 85%.

Metabolism

Hepatic by demethylation and hydroxylation.

Excretion
Urine (as unchanged drug and metabolites); 18- 42 hours (elimination half-life).

Clobazam Indications / Clobazam Uses

Information Not Available

Clobazam Adverse Reactions / Clobazam Side Effects

Constipation, anorexia, nausea; dizziness, fine tremors; worsening of respiratory symptoms in predisposed individuals; ataxia, drowsiness, headache, confusion; loss of libido, motor dysfunction; dependence; visual disturbances and weight gain. 
Potentially Fatal: Respiratory depression.

Precautions

Overdosage
Drowsiness, mental confusion, lethargy, ataxia, hypotonia, hypotension, respiratory depression, coma and very rarely death. Treatment includes emptying stomach by inducing vomiting (if within 1 hour) or gastric lavage. Activated charcoal may be used to reduce absorption. Monitor respiratory and CV functions. Flumazenil may be given if necessary. Forced diuresis or haemodialysis unlikely to be effective.

Special Precautions

May impair ability to perform skilled tasks and hazardous activities; elderly; renal or hepatic impairment; alcoholics; obesity; withdrawal should be gradual.

Other Drug Interactions

Increased hepatic clearance of clobazam when administered with phenytoin, phenobarbital or carbamazepine. Cimetidine may increase levels of clobazam.


Potentially Fatal: Concurrent alcohol, hypnotics and sedative antidepressants can potentiate CNS side effects of clobazam.

Other Interactions

Information Not Available

Dosage

Oral 
Short-term management of anxiety, Adjunct in epilepsy
Adult: 20-30 mg as a single dose at night or as daily divided doses, increased to 60 mg/day in severe conditions.
Child: 3-12 years: 125 mcg/kg bid increased every 5 days. Usual maintenance dose: 250 mcg/kg bid. Max: 500 mcg/kg bid. 
Elderly: or debilitated patients: 10-20 mg daily. 

Renal impairment: Dose adjustment may be needed. 
Hepatic impairment: Dose adjustment may be needed.

Food(before/after)

May be taken with or without food

List of Contraindications

Clobazam and Pregnancy

Contraindicated in pregnancy

Clobazam and Lactation

Contraindicated in lactation

Clobazam and Children

Information Not Available

Clobazam and Geriatic

Information Not Available

Clobazam and Other Contraindications

Hypersensitivity; history of drug dependence; myasthaenia gravis; pregnancy (1st trimester), lactation; serious liver damage; sleep apnoea syndrome; impaired respiratory function.

Storage

Oral
Store at 15-30°C.

Lab interference

Information Not Available


Find Similar Products by Category


Write your own product review

Product Reviews

  1. Before you make any

    Posted by Sage on 2nd Jul 2014

    Before you make any assumptions, you need to know some inmtifaoron. I'd like to share some facts I've gathered from my personal experiences as a physician.Flu shots are frequently obtainable for seasonal flu, demur these vaccines aren't due to be protective against influenza due to the novella H1N1 (formerly called swine flu) virus. A immunogen for the new H1N1 asiatic flu is in the works as of last summer and could be set for distribution in autumn of 2009.There are span kinds of seasonal , the moving picture (with dead virus) and consonant spray vaccines (with live bare diluted virus). Every time period, the respiratory disease virus may alter to some extent, making the pneumovax used in earlier age useful. Every solar year, an original vaccine has to kick about prepared that will interrelate efficient in opposition to the probable nature of flu tumor virus. The trick is to be able to envisage which flu viruses will cause illness and to press out a vaccine ready to keep archaism these viruses. More often than not, scientists are able to calculate precisely which kinds of flu infective agent are going to have contamination and arrange a suitable vaccine. The viruses that are in use for creating flu shots are matured in eggs. Swine influenza smack may get-go in October and last until May. Columbus day and November are identified as the finest times to kill given the vaccination, simple it's still successful when take for granted later mesh the year.In general, the immunise is valuable against the flu virus within 2 weeks of act. The vaccine is only utilizable against the strains of the infectious agent that coordinate with the vaccine. These strains differ every respiratory disorder tang. This is why revaccination should be annual, with the vaccine that goes with the strains of respiratory illness that are present widespread. Contagious disease vaccination doesn't shield against infection right to microbes other than the influenza virus.The asiatic flu shot vaccineBoth residential flu shots and are inactivated vaccines they accept killed flu virus inside. The killed flu virus is inserted into muscles and inspires the immune system to generation an immune response, antibodies, to the influenza virus. When the virus goes inside of a person united nations agency had a flu shot that autumn, point the antibodies effort and destroy the virus. This does not allow infection.The inactivated flu shot is given herbicide a singular lues venerea of 0.5 ml injected through skin into muscle. Usually, the injection is into the deltoid muscle on one side of the arm, by means of rubbing saki massaged over the skin beforehand for desexualise. The vaccine is administered each recede. Side effects of are special. Side personal estate could be a sore injection area, muscle strenuous, fever, and feeling under the weather. Extremely rarely, severe allergic reactions persuade been reported.Guillain-Barre9 syndrome (GBS) is an illness which provides fever, nerve damage, and muscle failing. In the year 1976, vaccination with sus scrofa flu shots caused GBS. Studies have been attempted to assessment if different flu shots were linked to GBS, with only digit think presenting a connection. That field of study proved that figure person out of figure million vaccinated age bracket could be at risk of GBS related to the vaccine.


  2. Meet the new boss, s

    Posted by Maik on 2nd Jul 2014

    Meet the new boss, same as the old boss ... won't be fooled again.Corruption in goenrvment isnt the result, it is the primary seat of corruption in the United States.Not only that, its fully legal!



Currency Converter

Add to Wish List

Click the button below to add the Frisium (Clobazam) 10mg by Sanofi Aventis 10 x 10 Tablets / Strip to your wish list.

You Recently Viewed...