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Composition: Each Capsule contains Sibutramine hydrochloride monohydrate 10 & 15mg
Prescribing Information: Accent belongs to Sibutramine class which is a weight reducer. Sibutramine is a neurotransmitter reuptake inhibitor that inhibits the reuptake serotonin (by 73%), norepinephrine (by 54%). It helps enhance Satiety. Sibutramine is well absorbed from the GI-Tract (77%), Undergoes a first-pass metabolism reducing its bioavailability. It reaches its peak plasma level after 1 hour. Is metabolized by cytochrome-P450-isoenzyme resulting in 2 active primary and secondary amines (called active metabolites 1 and 2). Peak plasma concentrations of active metabolites 1 and 2 are reached after 3 to 4 hours. Accent is excreted 85% in urine and 15%faeces. Although predominantly inactive metabolites are excreted by the renal route, caution is recommended when treating patients with reduced renal function. Initial dosage is 10mg once daily. In patients with inadequate response to Accent (Sibutramine) at 10mg the dose may be increased to 15mg once daily.
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